Somatostatin and somatostatin analogues in medullary thyroid carcinoma
| Autor: | Cullen Mj, O'Byrne Kj, Freyne Pj, Sweeney E, N J O'Hare |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Calcitonin Male Pathology medicine.medical_specialty Octreotide Scintigraphy Thyroid carcinoma Immunoglobulin Fab Fragments medicine Humans Radiology Nuclear Medicine and imaging Receptors Somatostatin Thyroid Neoplasms Aged medicine.diagnostic_test Somatostatin receptor business.industry Indium Radioisotopes Thyroid Antibodies Monoclonal General Medicine Middle Aged medicine.disease Carcinoembryonic Antigen Somatostatin medicine.anatomical_structure Radioimmunodetection Medullary carcinoma Carcinoma Medullary Female Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Nuclear Medicine Communications. 17:810-816 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199609000-00013 |
| Popis: | Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour characterized by the production and secretion of calcitonin. MTC tumours may express functional somatostatin receptors (hSSTR). A significant proportion of hSSTR receptor-positive MTC tumours, including metastatic disease, may be visualized in vivo through 111 In-pentetreotide scintigraphy. Four patients with recurrent/metastatic disease, who had previously been assessed with 111 In-anti-CEA monoclonal antibody fragment [F(ab') 2 ] imaging, were evaluated. 111 In-pentetreotide scintigraphy localized all known disease sites. Furthermore, mediastinal disease was detected in one patient with negative conventional and 111 In-anti-CEA F(ab') 2 imaging studies. The detection of somatostatin within the tumour (2 patients), or negative octreotide challenges (2 patients), did not affect the outcome of 111 In-pentetreotide scintigraphy. In conclusion, 111 In-pentetreotide scintigraphy appears at least as effective as 111 In-anti-CEA F(ab') 2 imaging and should be considered in the diagnostic evaluation of MTC, particularly in the setting of recurrent/metastatic disease not detected by conventional means. |
| Databáze: | OpenAIRE |
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