End-systolic Pressure–Dimension Relationship ofin situMouse Left Ventricle
| Autor: | Arthur M. Feldman, Clarence C. Wu, Marc D. Feldman, Charles F. McTiernan, Christine M. Mahler, Toru Kubota |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Cardiac function curve In situ medicine.medical_specialty Cardiotonic Agents Systole Heart Ventricles Blood Pressure Mice Transgenic Ventricular Function Left Contractility Mice Dimension (vector space) Internal medicine medicine.artery Ascending aorta medicine Animals Molecular Biology Monitoring Physiologic Chemistry Hemodynamics Isoproterenol Anatomy Apex (geometry) Sonomicrometry medicine.anatomical_structure Ventricle Cardiology Female Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of Molecular and Cellular Cardiology. 30:357-363 |
| ISSN: | 0022-2828 |
| DOI: | 10.1006/jmcc.1997.0599 |
| Popis: | The increasing popularity of genetically engineered mice in cardiovascular research has made it important to evaluate cardiac function in small animals. We have developed a system to enable simultaneous pressure-dimension analysis of the mouse left ventricle. The chest was opened under anesthesia, and a 1.4 F micromanometer catheter was inserted into the left ventricle through the apex. A pair of sonomicrometry crystals were attached to the anterior and posterior walls using tissue adhesive. Pressure and dimension were recorded simultaneously at baseline and after isoproterenol injection (1 micro g, intraperitoneally). The ascending aorta was occluded transiently to estimate the end-systolic pressure-dimension relationship (ESPDR), which was parameterized subsequently by the quadratic equation: Pes=C2 X (Des-D0)2+E0 X (Des-D0), where Pes is end-systolic pressure, Des is end-systolic dimension, D0 is the dimension axis intercept, E0 is the local slope at D0, and C2 is the curvilinearity coefficient. The maximum and minimum external dimensions at baseline were 5.82+/-0.50 (s.d.) mm and 5.49+/-0.46 mm with fractional shortening of 0.057+/-0.014 (n=12). The ESPDR was significantly curvilinear and increased convexity after isoproterenol injection (C2, -444+/-281 to -1113+/-780 mmHg/mm2, P |
| Databáze: | OpenAIRE |
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