Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
| Autor: | Jia-Rong Huang, Zi-Hao Xing, Na Zhao, Jin-Yan Chen, Meng-Ling Yuan, Hai-Hong Zhou, Xing-Wei Nan, Piao-Piao Ye, Xiao-Jian Yan, Qi-Wei Jiang, Meng-Ning Wei, Zhi Shi, Yao Li, Li-Na Xu, Yang Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Cell cycle checkpoint lcsh:RC254-282 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo medicine celastrol Original Research chemistry.chemical_classification reactive oxygen species Reactive oxygen species Cell growth apoptosis medicine.disease N-acetyl-cysteine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens In vitro 030104 developmental biology ovarian cancer chemistry Oncology Apoptosis Celastrol 030220 oncology & carcinogenesis Cancer research Ovarian cancer |
| Zdroj: | Frontiers in Oncology, Vol 9 (2019) Frontiers in Oncology |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2019.00002 |
| Popis: | Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer. |
| Databáze: | OpenAIRE |
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