The effect of selenium supplementation on skeletal and cardiac muscle in selenium-depleted patients

Autor: Jens Halkjær Kristensen, Nina Beyer, T. Rannem, Harriet Dige-Petersen, Rocco Liguori, Stig Jarnum, Jette Christiansen, Henning Laursen, Ellinor Hylander, Karin Ladefoged, Birte Hjort Jensen, Michael Linstow
Rok vydání: 1995
Předmět:
Cardiac function curve
Adult
medicine.medical_specialty
030309 nutrition & dietetics
Systole
Biopsy
Medicine (miscellaneous)
chemistry.chemical_element
Radionuclide ventriculography
Placebo
Gastroenterology
03 medical and health sciences
Selenium
0302 clinical medicine
Selenium deficiency
Diastole
Internal medicine
Surveys and Questionnaires
medicine
Humans
Muscle
Skeletal
Creatine Kinase
Radionuclide Ventriculography
Aged
0303 health sciences
Glutathione Peroxidase
Nutrition and Dietetics
Dose-Response Relationship
Drug
business.industry
Electromyography
Cardiac muscle
Heart
Stroke Volume
Middle Aged
Short bowel syndrome
medicine.disease
Long-Term Care
medicine.anatomical_structure
Parenteral nutrition
Endocrinology
chemistry
Food
Fortified
030211 gastroenterology & hepatology
Parenteral Nutrition
Total
business
Zdroj: JPEN. Journal of parenteral and enteral nutrition. 19(5)
ISSN: 0148-6071
Popis: The purpose of the present study was to evaluate the effect of sodium selenite on skeletal and cardiac muscular function in patients with severe Se deficiency.Skeletal and cardiac muscular function was investigated in 10 selenium depleted patients on long-term home parenteral nutrition because of short bowel syndrome. The following examinations were applied: Skeletal muscle biopsy, muscular force test (Kin-Com dynamometer test), electromyography (EMG) and radionuclide ventriculography. The patients were blindly randomized to intravenous supplementation with selenium 200 micrograms 5 to 7 times per week or placebo for 4 months. Hereafter the examinations were repeated. The patients randomized to placebo received selenium in an open study for a further 4 months and hereafter their skeletal and cardiac function was reevaluated.Plasma selenium increased to normal levels from median .21 mumol/l (range 0-.69) to 1.25 mumol/l (range .9-2.27) following selenium repletion. The muscle biopsies showed only minor abnormalities. The only change after selenium supplementation was a small but statistically significant increase of the mean diameter of fiber type 1. The muscle strength of the quadriceps muscle was unchanged after selenium substitution. EMG did not reveal signs of myopathy. The cardiac function was normal and remained unchanged.Despite severe selenium depletion ten patients on long term home parenteral nutrition had normal cardiac function, and no clinically significant signs of skeletal myopathy. The only change after selenium supplementation was a small but statistically significant increase of the mean diameter of muscle fiber type 1.
Databáze: OpenAIRE
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