Pattern of response to intzerstitial hyperthermia and brachytherapy for malignant intracranial tumour: A CT analysis
| Autor: | David W. Roberts, T. Nakajima, Christopher T. Coughlin, P J Hoopes, B.S. Trembly, John W. Strohbehn, T.P. Ryan |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Hyperthermia Cancer Research Physiology medicine.medical_treatment Brachytherapy Computed tomography Astrocytoma Lesion Physiology (medical) medicine Humans Microwaves Melanoma Aged medicine.diagnostic_test Brain Neoplasms business.industry Ct analysis Hyperthermia Induced Middle Aged Iridium Radioisotopes medicine.disease Combined Modality Therapy Radiation therapy Blood-Brain Barrier Female Microwave hyperthermia medicine.symptom Glioblastoma Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | International Journal of Hyperthermia. 9:491-502 |
| ISSN: | 1464-5157 0265-6736 |
| DOI: | 10.3109/02656739309005047 |
| Popis: | Interstitial microwave hyperthermia in combination with iridium-192 brachytherapy has been administered to 23 cases of malignant brain tumours in a phase one clinical trial to assess the feasibility and safety of this treatment. In order to quantify the acute and long-term response of tumour and surrounding brain to this treatment, a morphometric computed tomography scan analysis was performed in 18 evaluable patients. Volumes defined by the outer margin of the contrast-enhancing rim, by the hypodense necrotic region within the enhancing rim and by the surrounding hypodensity region were calculated from computer measurements. Hyperthermia equipment performance (HEP) was calculated for the evaluation of heating. After the treatments, the volume of the inner hypodensity region decreased in seven patients and the volume increased in 11 patients. In five patients, the outer margin of the contrast-enhancing lesion showed an initial increase in volume followed by a decrease and in these patients higher HEP and longer survival were observed significantly. The volume of the surrounding hypodensity region varied following treatments, but in most instances, the region subsequently increased in the interval immediately prior to death. Contribution of heat effect to these changes are discussed and the significance of aggressive heating, which provides transient opening of blood brain barrier, is shown. |
| Databáze: | OpenAIRE |
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