The physiological stress response and oxidative stress biomarkers in rainbow trout and brook trout from selenium-impacted streams in a coal mining region
| Autor: | Joseph B. Rasmussen, Alice Hontela, L. L. Miller, Vince P. Palace |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Vitamin endocrine system medicine.medical_specialty animal structures Antioxidant Trout medicine.medical_treatment Thyroid Gland Industrial Waste Toxicology medicine.disease_cause Alberta Lipid peroxidation Selenium chemistry.chemical_compound Rivers Species Specificity Stress Physiological Internal medicine medicine Animals Sex Characteristics biology Muscles Vitamin E Glutathione biology.organism_classification Coal Mining Oxidative Stress Endocrinology Liver chemistry Oncorhynchus mykiss Female Rainbow trout Biomarkers Water Pollutants Chemical Oxidative stress |
| Zdroj: | Journal of Applied Toxicology. 29:681-688 |
| ISSN: | 1099-1263 0260-437X |
| DOI: | 10.1002/jat.1458 |
| Popis: | Selenium (Se) is an essential element that can be toxic at concentrations slightly greater than those required for homeostasis. The main chronic toxic effects of Se in fish are teratogenic deformities, but Se can also activate the physiological stress response and redox cycle with reduced glutathione causing oxidative damage. Rainbow trout, Oncorhynchus mykiss, appear to be more sensitive to Se than brook trout, Salvelinus fontinalis. The objective of this study was to compare the physiological stress response (plasma cortisol, glucose, triiodothyronine, thyroxine, gill Na+/K+ ATPase, cortisol secretory capacity, K and liver somatic index) and oxidative stress biomarkers (liver GSH, GPx, lipid peroxidation, vitamin A and vitamin E) in rainbow trout (RNTR) and brook trout (BKTR) collected from reference and Se-exposed streams. The physiological stress response was not impaired (cortisol secretory capacity unchanged); although there were species differences in plasma cortisol and plasma glucose levels. Liver GSH, GPx and vitamin levels were higher in RNTR than BKTR, but lipid peroxidation levels were not different. The elevated GSH reserves may make RNTR more sensitive to Se-induced lipid peroxidation, but this may be offset by the RNTR's higher antioxidant (GPx and vitamin) levels. Species-specific biochemical differences may mediate differences in Se sensitivity and be used in aquatic Se risk assessments. |
| Databáze: | OpenAIRE |
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