c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain
| Autor: | Mark I. Ransome, Ann M. Turnley, Nikla R. Emambokus, Jon Frampton, Robert G. Ramsay, Sally Lightowler, Jordane Malaterre, Qing Yang, Sebastian Dworkin, Nancy R Nichols, Theo Mantamadiotis |
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| Rok vydání: | 2007 |
| Předmět: |
Ependymal Cell
PAX6 Transcription Factor Genes myb Gene Expression Cell Count Biology Mice Neurosphere In Situ Nick-End Labeling Animals Paired Box Transcription Factors RNA Messenger Progenitor cell Eye Proteins In Situ Hybridization Cell Proliferation Homeodomain Proteins Neurons Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors Neurogenesis Brain Cell Differentiation Cell Biology Immunohistochemistry Neural stem cell Cell biology DNA-Binding Proteins Repressor Proteins Neuroepithelial cell Adult Stem Cells Gene Expression Regulation Microscopy Electron Scanning Trans-Activators Molecular Medicine Stem cell Developmental Biology Adult stem cell |
| Zdroj: | Stem Cells. 26:173-181 |
| ISSN: | 1549-4918 1066-5099 |
| Popis: | Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.Disclosure of potential conflicts of interest is found at the end of this article. |
| Databáze: | OpenAIRE |
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