Modulation of T lymphocyte function by the angiogenesis inhibitor AGM-1470
| Autor: | B. R. Evans, M. S. Holm, M. A. Mitchell, A. E. Berger, K. A. Dortch, N. D. Staite |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Staphylococcal Toxoid
Angiogenesis T-Lymphocytes T cell CD3 Immunology chemical and pharmacologic phenomena Biology Lymphocyte Activation Toxicology Mice Tetanus Toxin Cyclohexanes medicine Animals Humans Pharmacology (medical) IL-2 receptor Cells Cultured Pharmacology O-(Chloroacetylcarbamoyl)fumagillol Antibiotics Antineoplastic hemic and immune systems T lymphocyte Molecular biology In vitro Angiogenesis inhibitor medicine.anatomical_structure biology.protein Interleukin-2 Sesquiterpenes CD8 |
| Zdroj: | Agents and Actions. 39:C86-C88 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01972729 |
| Popis: | The angiogenesis inhibitor AGM-1470 has recently been reported to inhibit collagen-induced arthritis in rats. To determine if the anti-arthritic effects of AGM-1470 might be due to T cell inhibition, we have studied its effects on T cell responses in vitro. Responses of human cells to tetanus toxoid (TT), and those of murine splenocytes to staphylococcal enterotoxin (SE), mitogens or a mls difference were inhibited by AGM-1470. Responses of human cells to SE, OKT3 and PHA were all partially inhibited on day 2 (d2) but not d3, and in fact were augmented on d6-8. The amount of IL-2 in SEA cultures was augmented on d4 and d5. There were no differences in the expression of CD3, CD4, CD8, CD25, CD45RA, CD45RO, LFA-1, VLA-4 or VLA-6 in inhibited cultures, except for slight decreases in CD25 and CD45RO in TT cultures. These results indicated that the angiogenesis inhibitor AGM-1470 also modulates human and murine lymphocyte function. |
| Databáze: | OpenAIRE |
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