Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model
| Autor: | Recai Ogur, Turgut Topal, Yildirim Karslioglu, Seher Altınel, Mehmet Toygar, Bulent Uysal, Hakan İstanbulluoğlu, Kahraman Ates, Ahmet Korkmaz, Ozcan Altinel, Salim Kemal Tuncer |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Paraquat Necrosis Poly ADP ribose polymerase Immunology 030204 cardiovascular system & hematology Lung injury Biology Pharmacology Poly(ADP-ribose) Polymerase Inhibitors medicine.disease_cause Neopterin Antioxidants Lipid peroxidation Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Pharmacology (medical) Lung Injury Disease Models Animal 030104 developmental biology chemistry PARP inhibitor Toxicity Benzamides Female Lipid Peroxidation medicine.symptom Poly(ADP-ribose) Polymerases Oxidative stress Biomarkers Injections Intraperitoneal |
| Zdroj: | Inflammopharmacology. 24(4) |
| ISSN: | 1568-5608 |
| Popis: | Paraquat (PQ) is a widely used herbicide. Exposure to PQ at toxic doses can result in fatal acute lung injury. Inhibition of the poly-(ADP-ribose) polymerase (PARP) enzyme alleviates inflammation and necrosis in various pathologies. Here we aimed to evaluate the effects of PARP inhibition on PQ-induced lung damage in a rat experimental model. Female Sprague-Dawley rats (n = 24) were allocated into three groups: sham, PQ and PQ + 3-aminobenzamide (3-AB) that is a PARP inhibitor, groups. Experimental lung injury was induced by administration of 15 mg/kg PQ intraperitoneally in PQ and PQ + 3-AB groups. 3-AB (10 mg/kg twice per day) was administered to the PQ + 3-AB group for four consecutive days. The animals were killed on the fifth day following PQ administration. Lung tissue and blood samples were collected and stored until analysis. Serum lactate dehydrogenase (LDH) and neopterin levels, tissue oxidative stress parameters, transforming growth factor-beta1 (TGF-β) levels and histological injury scores in the PQ + 3-AB group were significantly lower than in the PQ group (P |
| Databáze: | OpenAIRE |
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