Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma
| Autor: | Sheshadri Madhusudhana, Jennifer Hummel, Lawrence M. Weiss, Dennis P. O'Malley, Daniel C. Dim, Renuka Agrawal, Alexey Glazyrin, Kate E. Grimm |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Proto-Oncogene Proteins B-raf Pathology medicine.medical_specialty endocrine system diseases Dendritic Cell Sarcoma Interdigitating Lymphoma T-Cell Polymerase Chain Reaction Pathology and Forensic Medicine Langerhans cell histiocytosis medicine Humans neoplasms Histiocyte B-Lymphocytes business.industry Transdifferentiation General Medicine Dendritic cell Middle Aged medicine.disease Flow Cytometry Immunohistochemistry digestive system diseases Lymphoma Histiocytosis Langerhans-Cell Interdigitating dendritic cell sarcoma Cell Transdifferentiation Mutation Cancer research Female Indeterminate business |
| Zdroj: | Annals of diagnostic pathology. 19(3) |
| ISSN: | 1532-8198 |
| Popis: | BRAF V600E mutations have been reported in several histiocytic and dendritic cell neoplasms. In this case series, we report BRAF V600E-positive histiocytic and dendritic cell neoplasms in association with lymphomas and lymphoid proliferations. This is a review of cases with immunohistochemistry for BRAF V600E, with additional immunohistochemistry to categorize tumors. We report the first case of BRAF V600E-positive indeterminate cell tumor in association with angioimmunoblastic T-cell lymphoma. We also report a case of BRAF V600E-positive interdigitating dendritic cell sarcoma in a patient with positive B-cell polymerase chain reaction. It is unclear if these neoplasms developed as transdifferentiation of lymphoid neoplasms or if they developed independently. These cases illustrate the expanding spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors and suggest that attention should be paid to lymphomas for possible coincident presentation of these disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect