Early, Isolated Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma Presenting without Symptoms or Grossly Apparent Endoscopic Lesions and Diagnosed by Random Duodenal Biopsies
| Autor: | Tusar Desai, Issa Makki, Mitual Amin, Pradeep Khanal, Mihajlo Gjeorgjievski, Mitchell S. Cappell, Ann Marie Blenc |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Abdominal pain Lymphoma Duodenum Single Case Gastroenterology Asymptomatic Esophagogastroduodenoscopy Lesion 03 medical and health sciences 0302 clinical medicine Mucosa-associated lymphoid tissue lymphoma Internal medicine Medicine lcsh:RC799-869 medicine.diagnostic_test biology Helicobacter pylori business.industry biology.organism_classification Dysphagia medicine.anatomical_structure 030220 oncology & carcinogenesis Vomiting 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business |
| Zdroj: | Case Reports in Gastroenterology Case Reports in Gastroenterology, Vol 10, Iss 2, Pp 323-331 (2016) |
| ISSN: | 1662-0631 |
| Popis: | Clinical data regarding mucosa-associated lymphoid tissue lymphoma (MALToma) solely involving the duodenum are sparse because of the relative rarity of the disease. A comprehensive literature review revealed only 17 cases reported until 2004, and only a moderate number of cases have been reported since. MALToma can be asymptomatic in its very early stages but frequently produces localized or nonspecific symptoms, including early satiety, abdominal pain, vomiting, and involuntary weight loss in later stages. While gastric MALToma is strongly associated with gastric Helicobactor pylori infection, duodenal MALToma is often unassociated with H. pylori infection. A 74-year-old female presented with only dysphagia (without symptoms referable to a duodenal lesion), without systemic ‘B’ symptoms, and with no evident duodenal lesions at esophagogastroduodenoscopy; however, she was diagnosed with duodenal MALToma by pathologic examination of random duodenal biopsies performed to exclude celiac disease. An important clinical feature of this case is that duodenal MALToma was diagnosed by pathologic analysis of duodenal biopsies despite (1) no endoscopically apparent duodenal lesions; (2) duodenal involvement without gastric involvement; (3) lack of symptoms attributable to duodenal MALToma, and (4) absence of evident H. pylori infection. This work shows that early duodenal MALToma can be difficult to diagnose because of absent symptoms, absence of gastric involvement, absence of endoscopic abnormalities, and absence of H. pylori infection; it may require random duodenal biopsies for diagnosis. |
| Databáze: | OpenAIRE |
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