Maternal care alterations induced by repeated ethanol leads to heightened consumption of the drug and motor impairment during adolescence: a dose-response analysis
| Autor: | Juan Carlos Molina, Luciano Federico Ponce, Ricardo Marcos Pautassi, Norman E. Spear |
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| Rok vydání: | 2010 |
| Předmět: |
Drug
Male Adolescent Alcohol Drinking Offspring media_common.quotation_subject Physiology Experimental and Cognitive Psychology Behavioral Neuroscience chemistry.chemical_compound Lactation medicine Animals Humans Rats Wistar Maternal Behavior Motor skill media_common Ethanol Dose-Response Relationship Drug Age Factors Motor impairment Motor coordination Rats Disease Models Animal medicine.anatomical_structure chemistry Adolescent Behavior Motor Skills Anesthesia Rotarod Performance Test Female Self-administration Psychology |
| Zdroj: | Physiologybehavior. 103(5) |
| ISSN: | 1873-507X |
| Popis: | Maternal ethanol exposure during lactation induces behavioral alterations in offspring, including disruptions in motor skills and heightened ethanol ingestion during adolescence. These behavioral outcomes appear to partially depend on ethanol-induced disruptions in maternal care. The present study assessed motor skills and ethanol intake in adolescent rats raised by dams that had been repeatedly given ethanol during lactation. Female rats (postpartum days [PDs] 3–13) were administered ethanol (0.5, 1.5, or 2.5 g/kg) or vehicle every other day and allowed to freely interact with their pups. During adolescence, the offspring were evaluated for motor coordination (accelerating rotarod test) and oral ethanol self administration. The lowest maternal ethanol dose (0.5 g/kg) mildly affected motor performance, whereas the higher doses (1.5 and 2.5 g/kg) resulted in motor coordination impairment and greater ethanol intake. Maternal care behavior was affected by ethanol in a dose-dependent fashion. These results indicate that early experience with ethanol during lactation, even when the drug dosage is kept relatively low, leads to long-term consequences in offspring. Dose–response effects on maternal care behavior (i.e., nest building, crouching) may underlie disruptions in motor development and greater ethanol intake resulting from these early ethanol experiences. |
| Databáze: | OpenAIRE |
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