Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats
| Autor: | Peter H. Yu, Christina Chui Wa Poon, Shun Wan Chan, Candy Ngai-Yan Wong, Tsz Yan Lam, Mabel Yin Chun Yau, Alice Lai Shan Au, Yiu Wa Kwan, Ching-Yee Kwok, Sai Wang Seto |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Normal diet Dried fruit Medicine (miscellaneous) medicine.disease_cause Dietary supplement chemistry.chemical_compound Internal medicine Crataegus pinnatifida medicine TX341-641 chemistry.chemical_classification Nutrition and Dietetics biology Hawthorn Nutrition. Foods and food supply Chemistry Cholesterol Fatty liver biology.organism_classification medicine.disease Nitric oxide synthase High-fat diet Enzyme Endocrinology biology.protein Rat lipids (amino acids peptides and proteins) Oxidative stress Food Science |
| Zdroj: | Journal of Functional Foods, Vol 2, Iss 3, Pp 179-186 (2010) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2010.04.006 |
| Popis: | The hypocholesterolemic and atheroscleroprotective potentials of dietary consumption of hawthorn (dried fruit of Crataegus pinnatifida , Shan Zha) were investigated by monitoring plasma lipid profiles and aortic relaxation in Sprague–Dawley rats fed with either normal diet, high-cholesterol diet (HCD) or HCD supplemented with hawthorn powder (2%, w/w) (4 weeks). In HCD-fed rats, an increased plasma total cholesterol and LDL-cholesterol with a decreased HDL-cholesterol was observed, and consumption of hawthorn markedly suppressed the elevated total cholesterol and LDL-lipoprotein levels plus an increased HDL-cholesterol level. The blunted acetylcholine-induced, endothelium-dependent relaxation of isolated aortas of HCD-fed rats was improved by hawthorn. The development of fatty liver, an increased nitric oxide synthase (NOS) activity and an elevated oxidative stress (as estimated by the attenuated levels of anti-oxidant enzymes) associated with HCD were attenuated by hawthorn. Thus, the results demonstrated that hawthorn consumption provides overall beneficial effects on reversing HCD associated detrimental changes. |
| Databáze: | OpenAIRE |
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