Role of Polymeric Immunoglobulin Receptor in IgA and IgM Transcytosis
| Autor: | Ji-Yang Wang, Hao Wei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
polymeric immunoglobulin receptor (pIgR)
immunoglobulin transcytosis Review immunoglobulin transcytosis Catalysis Polymerization lcsh:Chemistry Inorganic Chemistry medicine Animals Humans Secretion marginal zone B and B1 cell-specific protein (MZB1) Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Mucosal immunity Spectroscopy Adaptor Proteins Signal Transducing Chemistry Organic Chemistry antibody secretion Receptors Polymeric Immunoglobulin General Medicine Polymeric IgA polymeric immunoglobulin receptor (pIgR) Marginal zone J chain Epithelium immunoglobulin A (IgA) immunoglobulin M (IgM) joining chain (J chain) marginal zone B and B1 cell-specific protein (MZB1) antibody secretion Computer Science Applications Cell biology Immunoglobulin A joining chain (J chain) medicine.anatomical_structure immunoglobulin M (IgM) lcsh:Biology (General) lcsh:QD1-999 Transcytosis Immunoglobulin M mucosal immunity immunoglobulin A (IgA) Polymeric immunoglobulin receptor |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 2284, p 2284 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric immunoglobulin receptor (pIgR). Secreted IgA and IgM have vital roles in mucosal immunity in response to pathogenic infections. Binding and recognition of polymeric IgA and IgM by pIgR require the joining chain (J chain), a small protein essential in the formation and stabilization of polymeric Ig structures. Recent studies have identified marginal zone B and B1 cell-specific protein (MZB1) as a novel regulator of polymeric IgA and IgM formation. MZB1 might facilitate IgA and IgM transcytosis by promoting the binding of J chain to Ig. In this review, we discuss the roles of pIgR in transcytosis of IgA and IgM, the roles of J chain in the formation of polymeric IgA and IgM and recognition by pIgR, and focus particularly on recent progress in understanding the roles of MZB1, a molecular chaperone protein. |
| Databáze: | OpenAIRE |
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