The Influence of Morphine on Cerebral 5-HT2A Availability in Dogs: a SPECT Study
| Autor: | Ingeborgh Polis, Bart De Spiegeleer, Jos Eersels, Kathelijne Peremans, Luc Duchateau, Antita Adriaens, Sylvia Van Dorpe, Stanislas Sys, Tim Waelbers, Simon Vermeire |
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| Přispěvatelé: | Radiology and nuclear medicine, NCA - Brain Imaging, Electronics and Informatics, Supporting clinical sciences |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
brain Serotonergic Reuptake Dogs Internal medicine Journal Article Radioligand Animals Medicine Receptor Serotonin 5-HT2A Radiology Nuclear Medicine and imaging Tomography Emission-Computed Single-Photon business.industry Research Support Non-U.S. Gov't morphine Human brain Endocrinology medicine.anatomical_structure Opioid Anesthesia Neuropathic pain Morphine Female Serotonin business medicine.drug |
| Zdroj: | Journal of Nuclear Medicine, 53(12), 1969-1973. Society of Nuclear Medicine Inc. Adriaens, A M, Polis, I E, Vermeire, S T, Waelbers, T, Duchateau, L, Sys, S U, Van Dorpe, S, Eersels, J L H, De Spiegeleer, B & Peremans, K 2012, ' The Influence of Morphine on Cerebral 5-HT2A Availability in Dogs: a SPECT Study ', Journal of Nuclear Medicine, vol. 53, no. 12, pp. 1969-1973 . https://doi.org/10.2967/jnumed.112.103796 |
| ISSN: | 0161-5505 |
| Popis: | UNLABELLED: The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150. METHODS: 5-HT(2A) binding was estimated with and without morphine pretreatment in 8 dogs. The 5-HT(2A) binding indices in the frontal, parietal, temporal, and occipital cortex and in the subcortical region were obtained by semiquantification. RESULTS: A significantly decreased 5-HT(2A) binding index was found in the morphine group for the right (morphine, 1.41 ± 0.06; control, 1.52 ± 0.10) and left (morphine, 1.44 ± 0.08; control, 1.55 ± 0.11) frontal cortices, with P = 0.012 and P = 0.040, respectively. No significant differences were noted for the other regions. CONCLUSION: Morphine decreased the frontocortical 5-HT(2A) availability, confirming an interaction between the 5-HTergic and the opioid systems. Whether this interaction is caused by decreased receptor density due to direct internalization or is the result of indirect actions, such as increased endogenous serotonin release, remains to be elucidated. |
| Databáze: | OpenAIRE |
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