Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease
| Autor: | Hong Kyun Kim, Dong Hee Yoon, Jeongho Kim, Hee Dong Eom, Kyoung-Pil Lee, Byung Jae Son, Myung Jun Kim, Jae Uk Jung |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Conjunctiva Disease Stain 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans Ocular Surface Disease Index In patient Inflammation business.industry Impression cytology Pathophysiology 030104 developmental biology medicine.anatomical_structure Tears 030221 ophthalmology & optometry Cytokines Dry Eye Syndromes business |
| Zdroj: | Eyecontact lens. 47(1) |
| ISSN: | 1542-233X |
| Popis: | Purpose To analyze the pathophysiological differences between patients with dry eye disease (DED) having different tear film break-up patterns (TBUPs). Methods This investigative analysis involved 91 eyes of 91 patients with DED who were divided into two groups: those with "dot" break-up pattern (group I) and those with "random" break-up pattern (group II). Clinical severity was evaluated using the Ocular Surface Disease Index (OSDI), Oxford stain score system (OSS) score, and tear film break-up time (TF-BUT). Eighteen patients in group I and 17 patients in group II were selected for sampling of tears and the conjunctiva, and the concentrations of inflammatory cytokines and mucin in the tears and conjunctival tissue were measured. Results Thirty-seven patients were classified as group I and 54 patients as group II. Patients in group I had a statistically lower TF-BUT and a higher OSS score than those in group II, whereas the OSDI was not statistically different between the groups. The concentrations of interleukin (IL)-6 and IL-8 were statistically higher in group I than those in group II. Impression cytology showed that the expression of IL-1β and IL-8 was higher in group I, whereas that of other genes was not statistically different. Conclusions We were able to clearly classify patients with DED with different TBUPs into two groups, and each group had different clinical and pathophysiological characteristics. In patients with the dot break-up pattern, the disease was strongly associated with ocular surface inflammation, as opposed to that in patients without this pattern. |
| Databáze: | OpenAIRE |
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