Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Autor: D. V. Yashin, L. P. Sashchenko, Tatiana N. Sharapova, E. A. Romanova
Rok vydání: 2017
Předmět:
lcsh:Immunologic diseases. Allergy
0301 basic medicine
CD4-Positive T-Lymphocytes
Cytotoxicity
Immunologic
Article Subject
CD3 Complex
Lymphocyte
medicine.medical_treatment
Cellular differentiation
Immunology
chemical and pharmacologic phenomena
Interleukin-7 Receptor alpha Subunit
03 medical and health sciences
Mice
0302 clinical medicine
Antigen
Antigens
Neoplasm
T-Lymphocyte Subsets
medicine
Immunology and Allergy
Animals
Humans
HSP70 Heat-Shock Proteins
IL-2 receptor
Interleukin-7 receptor
Cell Proliferation
Innate immune system
Chemistry
Interleukin-2 Receptor alpha Subunit
hemic and immune systems
Cell Differentiation
General Medicine
Neoplasms
Experimental
Immunity
Innate
Cell biology
030104 developmental biology
medicine.anatomical_structure
Cytokine
030220 oncology & carcinogenesis
Cytokines
Interleukin-2
lcsh:RC581-607
K562 Cells
K562 cells
HeLa Cells
Research Article
Zdroj: Journal of Immunology Research
Journal of Immunology Research, Vol 2018 (2018)
ISSN: 2314-7156
Popis: We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.
Databáze: OpenAIRE
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