Bioengineering strategies for inducing tolerance in autoimmune diabetes
| Autor: | Steinunn Baekkeskov, Jeffrey A. Hubbell, Edward A. Phelps |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Pharmaceutical Science Autoimmunity Bioengineering medicine.disease_cause Immune tolerance 03 medical and health sciences 0302 clinical medicine Immunopathology Insulin-Secreting Cells medicine Immune Tolerance Animals Humans Autoimmune disease Type 1 diabetes business.industry Pancreatic islets Immunotherapy medicine.disease 030104 developmental biology medicine.anatomical_structure Diabetes Mellitus Type 1 030220 oncology & carcinogenesis Immunology Beta cell business |
| Zdroj: | Advanced drug delivery reviews. 114 |
| ISSN: | 1872-8294 |
| Popis: | Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes. |
| Databáze: | OpenAIRE |
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