Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate

Autor:	Grzegorz Guzowski, Izabella Kręźel, Julita Graczyk
Rok vydání:	1998
Předmět:	Crystallography Chemistry Clinical Biochemistry interaction Pharmacology Biochemistry l1210 mouse leukemia Mitoguazone QD901-999 methotrexate (mtx) medicine Molecular Medicine Methotrexate mitoguazone analogues (am) medicine.drug
Zdroj:	Pteridines, Vol 9, Iss 4, Pp 217-221 (1998)
ISSN:	2195-4720 0933-4807
DOI:	10.1515/pteridines.1998.9.4.217
Popis:	Summary In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9e0b04ff7919cb48f0eec81820d941 https://doi.org/10.1515/pteridines.1998.9.4.217 Zobrazit plný text záznamu