Clinical features and next-generation sequencing landscape of essential thrombocythemia, prefibrotic primary myelofibrosis, and overt fibrotic primary myelofibrosis: a Chinese monocentric retrospective study

Autor: Lan Zhang, Xingnong Ye, Shuna Luo, Xiaofei Xu, Shengjie Wang, Keyi Jin, Yan Zheng, Xiaoqiong Zhu, Dan Chen, Jie Jin, Jian Huang
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 149:2383-2392
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-022-04067-1
Popis: Since prefibrotic primary myelofibrosis (pre-PMF) was recognized as a separate entity in the 2016 revised classification of MPN differed from essential thrombocythemia (ET) or overt fibrotic primary myelofibrosis (overt PMF), it has been a subject of debate among experts due to its indefinite diagnosis.We retrospectively reviewed the clinical parameters, haematologic information, and genetic mutations of patients who were diagnosed with myeloproliferative neoplasms (MPNs) according to the WHO 2016 criteria in China, including 56 ET patients, 19 pre-PMF patients, and 43 overt PMF patients.Pre-PMF patients exhibited higher leukocyte counts [14.2(6.0-28.1) × 10The results of this study indicated that a comprehensive evaluation of BM features, clinical phenotypes, haematologic parameters, and molecular profiles is needed for the accurate diagnosis and treatment of ET, pre-PMF, and overt PMF patients.
Databáze: OpenAIRE
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