Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling
| Autor: | Borhane Annabi, Stéphanie Albarao, Eric Vaillancourt-Jean, Amélie Vézina |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Stromal cell medicine.medical_treatment IκB kinase Biology Receptors Tumor Necrosis Factor Mice Progranulins Ciliogenesis medicine Animals Cilia Granulins Tumor Necrosis Factor-alpha Cilium Mesenchymal stem cell NF-kappa B Mesenchymal Stem Cells Cell biology I-kappa B Kinase Mice Inbred C57BL Cytokine Oncology Cancer cell Cancer research Intercellular Signaling Peptides and Proteins Tumor necrosis factor alpha Female Signal Transduction |
| Zdroj: | Cancer letters. 345(1) |
| ISSN: | 1872-7980 |
| Popis: | The primary cilium is a cell surface-anchored sensory organelle which expression is lost in hypoxic cancer cells and during mesenchymal stromal cells (MSC) adaptation to low oxygen levels. Since pro-inflammatory cues are among the early events which promote tumor angiogenesis, we tested the inflammatory cytokine tumor necrosis factor (TNF)-α and found that it triggered a dose-dependent loss of the primary cilia in MSC. This loss was independent of IFT88 expression, was abrogated by progranulin, an antagonist of the TNF receptor and required the NF-κB signaling intermediates IκB kinase α, β, and γ, as well as NF-κB p65. These findings strengthen the concept that the primary cilium may serve as a biomarker reflecting the tumor-supporting potential of MSC and their capacity to adapt to hypoxic and pro-inflammatory cues. |
| Databáze: | OpenAIRE |
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