Thermoplastic starch/ethylene vinyl alcohol/forsterite nanocomposite as a candidate material for bone tissue engineering
| Autor: | Mohammad Ali Shokrgozar, Reza Bagheri, Mohammad Amiri, Zahra Mahdieh, Morteza Mehrjoo, Masoud Eslami |
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| Rok vydání: | 2016 |
| Předmět: |
Bone Regeneration
Thermoplastic Materials science Starch Simulated body fluid Biocompatible Materials Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Cell Line Nanocomposites Biomaterials chemistry.chemical_compound Tensile Strength Spectroscopy Fourier Transform Infrared Cell Adhesion Humans Vitamin E Composite material Bone regeneration Cell Proliferation chemistry.chemical_classification Nanocomposite Tissue Engineering Silicon Compounds technology industry and agriculture food and beverages Biomaterial 021001 nanoscience & nanotechnology Biodegradable polymer 0104 chemical sciences chemistry Mechanics of Materials Thermogravimetry Self-healing hydrogels Microscopy Electron Scanning Polyvinyls 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 69:301-310 |
| ISSN: | 0928-4931 |
| Popis: | Recently, biodegradable polymers such as starch based blends have been well renowned in the biomedical field. Studies have considered them suitable for bone scaffolds, bone cements, tissue engineering scaffolds, drug delivery systems and hydrogels. The aim of this study was to synthesize nanocomposite biomaterial consisting a blend of thermoplastic starch and ethylene vinyl alcohol as the polymer matrix, and nano-structured forsterite as the ceramic reinforcing phase for bone tissue engineering applications. Furthermore, vitamin E was applied as a thermal stabilizer during melt compounding. Extrusion and injection molding were incorporated for melt blending and shaping of samples, respectively. With blending thermoplastic starch and ethylene vinyl alcohol, some properties of thermoplastic starch such as degradation rate and water absorption were modified. In addition, using nanoforsterite as the ceramic reinforcing phase resulted in the improvement of mechanical and biological traits. The addition of nanoforsterite decreased the weight loss of the thermoplastic starch and ethylene vinyl alcohol blend in simulated body fluid. Moreover, this addition modified the pH in the MTT (methyl thiazolyl tetrazolium) assay and stimulated the cell proliferation. Cell adhesion assays indicated a favorable interaction between cells and the biomaterial. The proposed nanocomposite has appropriate biocompatibility, as well as mechanical properties in order to be used in bone tissue engineering. |
| Databáze: | OpenAIRE |
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