Thoracic dust exposure is associated with lung function decline in cement production workers
| Autor: | Anne Kristin Møller Fell, Antonio Bergamaschi, Marit Skogstad, Helge Kjuus, Wijnand Eduard, Johny Kongerud, Karl-Christian Nordby, Yngvar Thomassen, Antonio Pietroiusti, Øivind Skare, Hilde P. Notø, Rolf Abderhalden |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Lung Diseases Male Vital capacity medicine.medical_specialty Vital Capacity Toxicology 03 medical and health sciences 0302 clinical medicine Models Forced Expiratory Volume Occupational Exposure Surveys and Questionnaires Settore MED/44 - Medicina del Lavoro Medicine Humans Lung volumes Longitudinal Studies Lung Inhalation exposure Aerosols Inhalation Exposure Models Statistical medicine.diagnostic_test business.industry Construction Materials Occupational Lung Disease Regression analysis Percentage point Dust Original Articles Statistical Middle Aged 030210 environmental & occupational health Surgery Occupational Diseases medicine.anatomical_structure 030228 respiratory system Female Regression Analysis business Arithmetic mean |
| Zdroj: | The European Respiratory Journal |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | We hypothesised that exposure to workplace aerosols may lead to lung function impairment among cement production workers. Our study included 4966 workers in 24 cement production plants. Based on 6111 thoracic aerosol samples and information from questionnaires we estimated arithmetic mean exposure levels by plant and job type. Dynamic lung volumes were assessed by repeated spirometry testing during a mean follow-up time of 3.5 years (range 0.7–4.6 years). The outcomes considered were yearly change of dynamic lung volumes divided by the standing height squared or percentage of predicted values. Statistical modelling was performed using mixed model regression. Individual exposure was classified into quintile levels limited at 0.09, 0.89, 1.56, 2.25, 3.36, and 14.6 mg·m−3, using the lowest quintile as the reference. Employees that worked in administration were included as a second comparison group. Exposure was associated with a reduction in forced expiratory volume in 1 s (FEV1), forced expiratory volume in 6 s and forced vital capacity. For FEV1 % predicted a yearly excess decline of 0.84 percentage points was found in the highest exposure quintile compared with the lowest. Exposure at the higher levels found in this study may lead to a decline in dynamic lung volumes. Exposure reduction is therefore warranted. Cement dust exposure at levels comparable to stated workplace exposure limits may lead to obstructive lung changes http://ow.ly/Zl7ny |
| Databáze: | OpenAIRE |
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