Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats
| Autor: | Ilić, Spomenko, Drmić, Domagoj, Žarković, Kamelija, Kolenc, Danijela, Ćorić, Marijana, Brčić, Luka, Kliček, Robert, Radić, Božo, Sever, Marko, Djuzel, Viktor, Ivica, Mihovil, Boban Blagaić, Alenka, Zoričić, Zoran, Anić, Tomislav, Zoričić, Ivan, Džidić, Senka, Seiwerth, Sven, Sikirić, Predrag |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Molecular Sequence Data Stomach Diseases Ibuprofen White matter Weight loss Internal medicine medicine Animals paracetamol hepatic encephalopathy convulsions pentadecapeptide BPC 157 rats Amino Acid Sequence Rats Wistar Hepatic encephalopathy Pharmacology Behavior Animal business.industry organic chemicals Stomach Brain Organ Size medicine.disease Anti-Ulcer Agents Rats medicine.anatomical_structure Endocrinology Dentate nucleus Liver Cerebral cortex Gastric Mucosa Anesthesia Brain Injuries Hepatic Encephalopathy Toxicity medicine.symptom business Peptides medicine.drug Hepatomegaly |
| DOI: | 10.1016/j.ejphar.2011.05.038 |
| Popis: | Chronic ibuprofen (0.4 g/kg intraperitoneally, once daily for 4 weeks) evidenced a series of pathologies, not previously reported in ibuprofen-dosed rats, namely hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values with prolonged sedation/unconsciousness, and weight loss. In particular, ibuprofen toxicity was brain edema, particularly in the cerebellum, with the white matter being more affected than in gray matter. In addition, damaged and red neurons, in the absence of anti-inflammatory reaction was observed, particularly in the cerebral cortex and cerebellar nuclei, but was also present although to a lesser extent in the hippocampus, dentate nucleus and Purkinje cells. An anti-ulcer peptide shown to have no toxicity, the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10 μg, 10 ng/kg) inhibited the pathology seen with ibuprofen (i) when given intraperitoneally, immediately after ibuprofen daily or (ii) when given in drinking water (0.16 μg, 0.16 ng/ml). Counteracted were all adverse effects, such as hepatic encephalopathy, the gastric lesions, hepatomegaly, increased liver serum values. In addition, BPC 157 treated rats showed no behavioral disturbances and maintained normal weight gain. Thus, apart from efficacy in inflammatory bowel disease and various wound treatments, BPC 157 was also effective when given after ibuprofen. |
| Databáze: | OpenAIRE |
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