Midlife Long-Hour Working and Later-life Social Engagement Are Associated with Reduced Risks of Mild Cognitive Impairment among Community-Living Singapore Elderly
| Autor: | Lei Feng, Guo-Dong Lu, Kai-Yong Huang, Xiao-Wei Huang, Xiao-Xiao Hu, Xian-Yan Tang, Jing-Huan Deng, Xiao Wei |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Gerontology Employment Male Time Factors Affect (psychology) Logistic regression Healthy Aging 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus medicine Dementia Humans Cognitive Dysfunction Longitudinal Studies Cognitive decline Stroke Aged Singapore business.industry General Neuroscience Age Factors Cognition General Medicine Social engagement medicine.disease Social Participation Psychiatry and Mental health Clinical Psychology 030104 developmental biology Logistic Models Female Independent Living Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 67(3) |
| ISSN: | 1875-8908 |
| Popis: | Mild cognitive impairment (MCI), as a transitional stage between normal aging and dementia, causes cognitive decline among one-fifth of elders aged 65 years and older. Health-related lifestyles (HRL) are generally regarded as modifiable influencing factors of cognitive decline. The present study investigated how HRLs at two different life stages (one at midlife and the other at later life) affect MCI occurrence among community-dwelling elders, as part of the Diet and Healthy Aging (DaHA) study in Singapore. The frequencies of major HRL activities were compared between 119 clinical diagnosed MCI cases and 632 normal aging controls with functional cognition. The associations of HRLs with MCI were determined by multivariate logistic regression analysis and adjusted according to known factors including age, childhood education, and major chronic diseases (hypertension, stroke, diabetes, and cataracts or glaucoma). Long-hour working in midlife (adjusted OR = 0.418 with 95% CI 0.215-0.812) and social engagement in later-life (adjusted OR = 0.532 with 95% CI 0.329-0.859) were associated with reduced risks of MCI, respectively. It is important to note that those elders who had both midlife long-hour working and later-life social engagement were related to the lowest risk of MCI (adjusted OR = 0.285 with 95% CI 0.143-0.565), when compared to the least active subgroup who neither had worked long hours in midlife nor participate in social activities in later-life. Therefore, the present study demonstrated that midlife long-hour working and later-life social engagement were modifiable factors for the maintenance of cognitive functions. |
| Databáze: | OpenAIRE |
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