Loss of Conventional Melanocytic Markers in Malignant Melanoma and Lymph Node Metastasis; an Uncommon but Dangerous Pitfall
| Autor: | Zsolt B. Argenyi, Oliver Chang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Lymphatic metastasis Pathology medicine.medical_specialty Skin Neoplasms Dermatology Lymph node metastasis Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences MART-1 Antigen 0302 clinical medicine Biomarkers Tumor medicine Humans Melanoma business.industry S100 Proteins General Medicine Middle Aged medicine.disease Lymphatic Metastasis 030220 oncology & carcinogenesis Melanoma-Specific Antigens business gp100 Melanoma Antigen |
| Zdroj: | The American Journal of Dermatopathology. 39:760-763 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000000737 |
| Popis: | Although malignant melanomas exhibit a wide range of immunophenotypes, concurrent loss of all 3 conventional melanocytic markers (S-100, Melan-A, and HMB-45) is relatively rare. We report a case of primary malignant melanoma with lymph node metastasis, both exhibiting loss of immunoreactivity for conventional melanocytic markers, while aberrantly expressing epithelial antigenicity (pancytokeratin, CAM 5.2). |
| Databáze: | OpenAIRE |
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