Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

Autor: Päivi Heikkilä, Giovanni Bussolati, Angelika Reiner, Brigitte Sigal-Zafrani, C. de Miguel, Maria Drijkoningen, Peter Regitnig, Johannes L. Peterse, Manuela Lacerda, Roland Holland, Thomas Decker, Vincenzo Eusebi, S. Thorstenson, Jean-Pierre Bellocq, Simonetta Bianchi, D Faverly, Bettina Borisch, Clive A. Wells, C E Connolly, Janina Kulka, H. Kerner, Werner Boecker, E. Zozaya, Ian O. Ellis, Anna Sapino, Gábor Cserni, N Apostolikas, Isabel Amendoeira, Jocelyne Jacquemier, Peter A. Dervan, J. Martinez-Penuela, Fritz Rank, A.M. Tanous, C. W. Elston
Rok vydání: 2003
Předmět:
Cancer Research
Pathology
medicine.medical_specialty
micrometastasis
occult metastasis
Breast Neoplasms
Sensitivity and Specificity
survival
03 medical and health sciences
0302 clinical medicine
Breast cancer
breast cancer
sentinel lymph nodes
non-sentinel node metastasis
Predictive Value of Tests
Biopsy
Medicine
Humans
molecular analysis
Neoplasm Metastasis
Pathological
030304 developmental biology
Observer Variation
0303 health sciences
Frozen section procedure
medicine.diagnostic_test
business.industry
Reverse Transcriptase Polymerase Chain Reaction
Sentinel Lymph Node Biopsy
Micrometastasis
sentinel lymph nodes
breast cancer
micrometastasis
isolated tumour cell
occult metastasis
survival
non-sentinel node metastasis
frozen section
intraoperative cytology
molecular analysis
medicine.disease
Prognosis
frozen section
Work-up
3. Good health
Tumor microenvironment [UMCN 1.3]
intraoperative cytology
Oncology
030220 oncology & carcinogenesis
Predictive value of tests
isolated tumour cell
Practice Guidelines as Topic
Female
Lymph
Radiology
business
Zdroj: European Journal of Cancer, 39, 1654-67
European Journal of Cancer, 39, 12, pp. 1654-67
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(03)00203-x
Popis: Item does not contain fulltext Controversies and inconsistencies regarding the pathological work-up of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed.
Databáze: OpenAIRE
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