Dosimetric assessment of radiolabelled lipiodol as a potential therapeutic agent in colorectal liver metastases using combined CT and SPECT
| Autor: | Irving Taylor, S. Birch, John S. Fleming, S. Perring, R. E. Hind, V. Batty |
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| Předmět: |
Thorax
medicine.medical_specialty Rectum Single-photon emission computed tomography Gastroenterology Metastasis Iodine Radioisotopes Hepatic arterial infusion Internal medicine medicine Humans Dosimetry Radiology Nuclear Medicine and imaging medicine.diagnostic_test Rectal Neoplasms business.industry Liver Neoplasms Iodized Oil Radiotherapy Dosage General Medicine medicine.disease medicine.anatomical_structure Isotope Labeling Colonic Neoplasms Lipiodol Abdomen Nuclear medicine business medicine.drug |
| Zdroj: | Europe PubMed Central |
| Popis: | Lipiodol has previously been used as an agent for targeted radiotherapy by selective retention in primary hepatic tumours following direct hepatic arterial infusion. We have considered the potential dosimetry of 131I-labelled lipiodol in treating colorectal liver metastases. Fifteen patients with multiple colorectal liver metastases underwent selective hepatic angiography when 5 ml lipiodol labelled with 40 MBq 131I were infused. All patients underwent planar scintigraphy of the abdomen and thorax, single photon emission computed tomography (SPECT) of the liver and whole body counting on at least two occasions following lipiodol injection. Computed tomographic (CT) images of the liver were also taken typically 7 days postinjection. The lipiodol was found to deposit on the periphery of metastases of less than 10 cm diameter. In one patient a metastasis of diameter greater than 15 cm failed to infuse. In two patients the lobe of the liver containing metastases was not successfully infused. Overlay of CT and SPECT images confirmed concentration in metastases. Quantification of SPECT images indicated that between 55 and 100% (median 86%) of the injected activity was retained in the liver following injection, and tumour to liver ratios of dose delivered ranged from 1.21:1 to 4.7:1 (median 3.1:1). Tumour does ranged from 11.8 to 43.3 mGy MBq-1 injected. Dose to the lungs ranged from 0 to 46% of the liver dose (median 16%). Lipiodol has potential for treatment of colorectal liver metastases in targeted radiotherapy. |
| Databáze: | OpenAIRE |
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