Potentiation of in Vivo Anticancer Efficacy of Selenium Nanoparticles by Mushroom Polysaccharides Surface Decoration
| Autor: | Siu-To Cheung, Delong Zeng, Tianfeng Chen, Jianfu Zhao, Kar-Him Luk, Keith Kwong Hon Wong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Drug Compounding Mice Nude Nanoparticle chemistry.chemical_element Antineoplastic Agents Apoptosis Polysaccharide 01 natural sciences Selenium Polysaccharides In vivo Cell Line Tumor Neoplasms Animals Humans Particle Size Caspase chemistry.chemical_classification Mice Inbred BALB C biology Plant Extracts Chemistry 010401 analytical chemistry General Chemistry 0104 chemical sciences Bioavailability Biochemistry Toxicity biology.protein Nanoparticles Agaricales General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Journal of Agricultural and Food Chemistry. 67:2865-2876 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.9b00193 |
| Popis: | Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable anticancer activities. However, the effects of surface physicochemical properties on the biological actions remain elusive. Herein we decorated SeNPs with various water-soluble polysaccharides extracted from various mushrooms, to compare physical characteristics and anticancer profile of these SeNPs. The results showed that the prepared spherical SeNPs displayed particle sizes at 91-102 nm, and kept stable in aqueous solution for up to 13 weeks. However, different decoration altered the tumor selectivity of the SeNPs, while gastric adenocarcinoma AGS cells showed relative highest sensitivity. Moreover, PTR-SeNPs demonstrated potent in vivo antitumor, by inducing caspases- and mitochondria-mediated apoptosis, but showed no obvious toxicity to nomal organs. Taken together, this study offers insights into how surface decoration can tune the cancer selectivity of SeNPs and provides a basis for engineering particles with increased anticancer efficacy. |
| Databáze: | OpenAIRE |
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