Assessment of multi-contaminant exposure in a cancer treatment center: a 2-year monitoring of molds, mycotoxins, endotoxins, and glucans in bioaerosols

Autor: Natacha Heutte, Philippe Vérité, David Garon, Catherine Dubos Arvis, Marie-Yolande Louis, Stéphanie Gente, Virginie Séguin, Patrick Legendre, Edwige Votier, Véronique André, Stéphane Madelaine, Valérie Bouchart, Françoise Lemarié
Přispěvatelé: Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Veterinary medicine
[SDV]Life Sciences [q-bio]
Air Microbiology
010501 environmental sciences
01 natural sciences
Aspergillus fumigatus
chemistry.chemical_compound
Neoplasms
Glucans
General Environmental Science
[SDV.EE]Life Sciences [q-bio]/Ecology
environment
biology
food and beverages
General Medicine
Pollution
Hospitals
3. Good health
medicine.drug_formulation_ingredient
Air monitoring
Aspergillus
Air Pollution
Indoor
Mold
[SDE]Environmental Sciences
France
Seasons
Bioaerosols
Environmental Monitoring
030106 microbiology
Indoor bioaerosol
Penicillium brevicompactum
Management
Monitoring
Policy and Law
Risk Assessment
Microbiology
03 medical and health sciences
Air treatment
medicine
Humans
Mycotoxin
0105 earth and related environmental sciences
Aspergillus niger
Fungi
Penicillium
Cancer treatment center
Allergens
Mycotoxins
biology.organism_classification
Endotoxins
chemistry
13. Climate action
Cladosporium herbarum
Aspergillus versicolor
Zdroj: Environmental Monitoring and Assessment
Environmental Monitoring and Assessment, Springer Verlag (Germany), 2017, 189 (1), pp.31. ⟨10.1007/s10661-016-5751-z⟩
ISSN: 0167-6369
1573-2959
DOI: 10.1007/s10661-016-5751-z⟩
Popis: International audience; Indoor air quality in health care facilities is a major public health concern, particularly for immunocompromised patients who may be exposed to microbiological contaminants such as molds, mycotoxins, endotoxins, and (1,3)-ß-D-glucans. Over 2 years, bioaerosols were collected on a monthly basis in a cancer treatment center (Centre F. Baclesse, Normandy, France), characterized from areas where there was no any particular air treatment. Results showed the complexity of mycoflora in bioaerosols with more than 100 fungal species identified. A list of major strains in hospital environments could be put forward due to the frequency, the concentration level, and/or the capacity to produce mycotoxins in vitro: Aspergillus fumigatus, Aspergillus melleus, Aspergillus niger, Aspergillus versicolor, Cladosporium herbarum, Purpureocillium lilacinum, and Penicillium brevicompactum. The mean levels of viable airborne fungal particles were less than 30.530 CFU per m3 of air and were correlated to the total number of 0.30 to 20 μm particles. Seasonal variations were observed with fungal particle peaks during the summer and autumn. Statistical analysis showed that airborne fungal particle levels depended on the relative humidity level which could be a useful indicator of fungal contamination. Finally, the exposure to airborne mycotoxins was very low (only 3 positive samples), and no mutagenic activity was found in bioaerosols. Nevertheless, some fungal strains such as Aspergillus versicolor or Penicillium brevicompactum showed toxigenic potential in vitro.
Databáze: OpenAIRE
Externí odkaz: