Oscillatory potentials in electroretinogram as an early marker of visual abnormalities in vitamin A deficiency
Autor: | Kohei Sawada, Taisuke Uehara, Toyohiko Aoki, Akiyoshi Suganuma, Kazuo Tsukidate, Motohiro Shiotani, Dai Kakiuchi, Kyoko Nakano-Ito |
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Rok vydání: | 2013 |
Předmět: |
Vitamin
Male Cancer Research medicine.medical_specialty genetic structures Vision Disorders Biology Biochemistry Photoreceptor cell Retina chemistry.chemical_compound Internal medicine Oscillometry Rats Inbred BN Genetics medicine Electroretinography Animals Papilledema Molecular Biology Vitamin A Deficiency Retinal medicine.disease eye diseases Ganglion Rats Vitamin A deficiency medicine.anatomical_structure Endocrinology Oncology chemistry Apoptosis Cancer research Molecular Medicine sense organs medicine.symptom Erg |
Zdroj: | Molecular medicine reports. 11(2) |
ISSN: | 1791-3004 |
Popis: | Vitamin A deficiency (VAD) caused by malnutrition and certain intestinal diseases induces visual impairments, including night blindness and photoreceptor cell dysfunction as indicated by reduced a‑ and b‑waves in an electroretinogram (ERG). The effects of VAD on the inner retinal layer cells, including amacrine and ganglion cells, remain to be elucidated. The functions of these cells are reflected in oscillatory potentials (OPs), another component of the ERG. The present study investigated inner retinal layer cell function in VAD rats by analyzing OPs. In the present study, VAD was induced by feeding Brown Norway rats a vitamin A deficient diet for 10 weeks. A reduced body weight and peri‑papillary opacification indicative of papilledema without histopathological alterations were observed, which are considered early symptoms of VAD. At this stage, the ERG revealed reduced OPs as well as a‑ and b‑waves at various intensities of light stimulation. Further analysis indicated that the ratio of the alterations in OPs was more significant than those of a‑ and b‑waves. After 5 weeks of recovery, these changes returned to control levels. These results suggest that OPs are the most sensitive and early marker of VAD‑associated visual impairment in the ERG. |
Databáze: | OpenAIRE |
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