Histamine stimulation of digestive enzyme secretion byin vitro rabbit pancreas
| Autor: | C. Liebow, John E. Franklin |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Physiology Trypsinogen Secretory Rate Mepyramine Histamine Antagonists Chymotrypsinogen In Vitro Techniques Biology chemistry.chemical_compound Internal medicine medicine Animals Secretion Amylase Cimetidine Pancreas Pyrilamine Gastroenterology Lipase Stimulation Chemical Drug Combinations Endocrinology chemistry Amylases Pancreatin biology.protein Rabbits Histamine medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 27:234-241 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf01296922 |
| Popis: | Histamine (10(-3) M) was found to stimulate pancreatic enzyme secretion from in vitro isolated rabbit pancreas preparations. Histamine produced a peak and then a sustained stimulated secretory rate. Secretion of amylase, lipase, trypsinogen, chymotrypsinogen, and total radio active protein were all found to be stimulated. Although fluid output was slightly increased by histamine, enzyme concentrations in secretion were elevated. This, along with the observed sustained release rate, rules out washout effects. Histamine produced a significant response at 10(-5) M with ED50 being about 3 x 10(-5) M and maximal responses produced by 10(-3) M. Histamine stimulation can be blocked with mepyramine (10(-4) or 10(-5) M) or mepyramine in combination with cimetidine. The observed behavior of the pancreas suggests a similarity with pepsinogen secretion in the stomach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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