Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression
| Autor: | Lucia Funghi, Patrizia Carrarelli, Stefano Luisi, Felice Petraglia, Simone Bruni, Felice Arcuri |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Naproxen Stromal cell Endocrinology Diabetes and Metabolism media_common.quotation_subject Naproxen Sodium dysmenorrhea Endometrium Dinoprostone prostaglandins 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Internal medicine hydroxyprostaglandin dehydrogenase medicine Humans Secretion Cyclooxygenase-2 naproxen sodium Menstrual cycle Cells Cultured media_common 030219 obstetrics & reproductive medicine biology business.industry Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal Obstetrics and Gynecology medicine.anatomical_structure Cyclooxygenase 2 030220 oncology & carcinogenesis biology.protein Tumor necrosis factor alpha Female Cyclooxygenase Stromal Cells business medicine.drug |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 32(4) |
| ISSN: | 1473-0766 |
| Popis: | Dysmenorrhea, defined as painful cramps occurring immediately before or during the menstrual period, is a common symptom of different gynecological diseases. An acute uterine inflammatory response driven by prostaglandins (PGs) is responsible for painful symptoms. Progesterone withdrawal is responsible for activation of cyclooxygenase (COX-2) enzyme and decrease of hydroxyprostaglandin dehydrogenase (HPDG) with consequent increased secretion of PGs secretion, inducing uterine contractility and pain. The most widely used drugs for the treatment of pelvic pain associated with menstrual cycle are non steroidal anti-inflammatory drugs (NSAIDs). The uterine site of action of these drugs is still not defined and the present study evaluated the effect of naproxen sodium in cultured human endometrial stromal cells (HESC) collected from healthy women. PGE2 release was measured by ELISA; COX-2 and HPDG mRNA expression were assessed by qRT-PCR. Naproxen sodium did not affect HESC vitality. Naproxen sodium significantly decreased PGE2 secretion (p |
| Databáze: | OpenAIRE |
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