Routine screening for SARS CoV-2 in unselected pregnant women at delivery

Autor: Manuel Schepeler, Antonia Barros, Max Monckeberg, Pilar Díaz-Corvillón, Javier Caradeux, Jyh-Kae Nien, Sebastian E. Illanes, Arturo Soldati
Rok vydání: 2020
Předmět:
Viral Diseases
Pediatrics
Cross-sectional study
Maternal Health
Artificial Gene Amplification and Extension
Polymerase Chain Reaction
Neonatal Care
law.invention
Labor and Delivery
COVID-19 Testing
Medical Conditions
0302 clinical medicine
Obstetrics and gynaecology
Pregnancy
law
Prevalence
Medicine and Health Sciences
Mass Screening
030212 general & internal medicine
Chile
Pregnancy Complications
Infectious
Asymptomatic Infections
Virus Testing
education.field_of_study
030219 obstetrics & reproductive medicine
Multidisciplinary
Medical record
Obstetrics and Gynecology
Intensive care unit
Infectious Diseases
Medicine
Female
medicine.symptom
Coronavirus Infections
Research Article
Adult
medicine.medical_specialty
Science
Pneumonia
Viral
Population
Research and Analysis Methods
Asymptomatic
Betacoronavirus
Young Adult
03 medical and health sciences
Diagnostic Medicine
medicine
Humans
Molecular Biology Techniques
education
Pandemics
Molecular Biology
Mass screening
SARS
Clinical Laboratory Techniques
SARS-CoV-2
business.industry
Infant
Newborn
COVID-19
Biology and Life Sciences
Neonates
Covid 19
Reverse Transcriptase-Polymerase Chain Reaction
medicine.disease
Health Care
Cross-Sectional Studies
Birth
Women's Health
Pregnant Women
Neonatology
business
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239887 (2020)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0239887
Popis: BackgroundSouth America has become the epicenter of coronavirus pandemic. It seems that asymptomatic population may contribute importantly to the spread of the disease. Transmission from asymptomatic pregnant patients' needs to be characterized in larger population cohorts and symptom assessment needs to be standardized.ObjectiveTo assess the prevalence of SARS CoV-2 infection in an unselected obstetrical population and to describe their presentation and clinical evolution.MethodsA cross-sectional study was designed. Medical records of pregnant women admitted at the Obstetrics & Gynecology department of Clínica Dávila for labor & delivery, between April 27th and June 7th, 2020 were reviewed. All patients were screened with RT-PCR for SARS CoV-2 at admission. After delivery, positive cases were inquired by the researchers for clinical symptoms presented before admission and clinical evolution. All neonates born from mothers with confirmed SARS CoV-2 were isolated and tested for SARS CoV-2 infection.ResultsA total of 586 patients were tested for SARS CoV-2 during the study period. Outcomes were obtained from 583 patients which were included in the study. Thirty-seven pregnant women had a positive test for SARS CoV-2 at admission. Cumulative prevalence of confirmed SARS CoV-2 infection was 6.35% (37/583) [CI 95%: 4.63-8.65]. From confirmed cases, 43.2% (16/37) were asymptomatic. From symptomatic patients 85.7% (18/21) had mild symptoms and evolved without complications and 14.3% (3/21) presented severe symptoms requiring admission to intensive care unit. Only 5.4% (2/37) of the neonates born to mothers with a positive test at admission had a positive RT-PCR for SARS CoV-2.ConclusionIn our study nearly half of pregnant patients with SARS CoV-2 were asymptomatic at the time of delivery. Universal screening, in endemic areas, is necessary for adequate patient isolation, prompt neonatal testing and targeted follow-up.
Databáze: OpenAIRE
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