A study of deoxyribonucleotide metabolism and its relation to DNA synthesis
| Autor: | F. Heinmets, R. H. Leary |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Purine
chemistry.chemical_classification DNA synthesis Guanine Deoxyribonucleotides Biophysics DNA Cell Biology Biology Models Biological chemistry.chemical_compound Pyrimidines chemistry Biochemistry Biosynthesis Purines Pyrimidine metabolism Animals Humans Computer Simulation Nucleotide Purine metabolism |
| Zdroj: | Cell Biophysics. 18:263-277 |
| ISSN: | 0163-4992 |
| DOI: | 10.1007/bf02989818 |
| Popis: | A model system (1) was established to analyze purine and pyrimidine metabolism. This system has been expanded to include macrosimulation of DNA synthesis and the study of its regulation by terminal deoxynucleoside triphosphates (dNTPs) via a complex set of interactions. Computer experiments reveal that our model exhibits adequate and reasonable sensitivity in terms of dNTP pool levels and rates of DNA synthesis when inputs to the system are varied. These simulation experiments reveal that in order to achieve maximum DNA synthesis (in terms of purine metabolism), a proper balance is required in guanine and adenine input into this metabolic system. Excessive inputs will become inhibitory to DNA synthesis. In addition, studies are carried out on rates of DNA synthesis when various parameters are changed quantitatively. The current system is formulated by 110 differential equations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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