Rescue of TCA Cycle Dysfunction for Cancer Therapy

Autor:	Jubert Marquez, Kim Ah, Park N, Bayalagmaa Nyamaa, Jin Han, Nguyen Att, Flores J
Rok vydání:	2019
Předmět:	IDH 0301 basic medicine Cell Review SDH Oxidative phosphorylation Mitochondrion MDH FH 03 medical and health sciences 0302 clinical medicine microRNA medicine cancer CRISPR/Cas9 miRNA chemistry.chemical_classification business.industry Cancer General Medicine medicine.disease TCA Cell biology mitochondria Citric acid cycle 030104 developmental biology medicine.anatomical_structure Enzyme chemistry 030220 oncology & carcinogenesis business Function (biology)
Zdroj:	Journal of Clinical Medicine
ISSN:	2077-0383
Popis:	Mitochondrion, a maternally hereditary, subcellular organelle, is the site of the tricarboxylic acid (TCA) cycle, electron transport chain (ETC), and oxidative phosphorylation (OXPHOS)—the basic processes of ATP production. Mitochondrial function plays a pivotal role in the development and pathology of different cancers. Disruption in its activity, like mutations in its TCA cycle enzymes, leads to physiological imbalances and metabolic shifts of the cell, which contributes to the progression of cancer. In this review, we explored the different significant mutations in the mitochondrial enzymes participating in the TCA cycle and the diseases, especially cancer types, that these malfunctions are closely associated with. In addition, this paper also discussed the different therapeutic approaches which are currently being developed to address these diseases caused by mitochondrial enzyme malfunction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1351a0b3f65bd22faed8c1f23c3f23 https://doi.org/10.3390/jcm8122161 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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