Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is the disease identical to Dent's disease in United Kingdom?
| Autor: | Shinya Tsuchida, Hiroshi Shiraga, Hidehiko Kawato, Hiroshi Hayakawa, Kunihiko Akagi, Takashi Igarashi, Haruo Kawaguchi, Tatsuhiro Yamanaka, Kunimasa Yan |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty X Chromosome Adolescent urologic and male genital diseases Kidney Gastroenterology Kidney Calculi Japan Calcinosis Internal medicine medicine Humans Hypercalciuria Child Proteinuria Dent's disease biology business.industry CLCN5 Incidence Fanconi syndrome medicine.disease Fanconi Syndrome female genital diseases and pregnancy complications Surgery Nephrocalcinosis medicine.anatomical_structure Child Preschool biology.protein Calcium Electrophoresis Polyacrylamide Gel Female medicine.symptom business Tomography X-Ray Computed |
| Zdroj: | Nephron. 69(3) |
| ISSN: | 1660-8151 |
| Popis: | Idiopathic low-molecular-weight (LMW) proteinuria is a newly described renal disease in Japan and Italy. We report on 7 patients who manifested bilateral or unilateral nephrocalcinosis, as demonstrated by abdominal computed tomography scans. Renal histology revealed calcinosis of renal tubules in 2 patients. Computed tomography is a reliable method for the detection of nephrocalcinosis in this disorder. Hypercalciuria was also seen in 6 patients. A calcium-loading test performed in 2 patients suggested that hypercalciuria was of renal origin. Although the true pathogenesis is still not known, hypercalciuria and nephrocalcinosis appear to be a common complication in patients with idiopathic LMW proteinuria. These complications and clinical features suggest that idiopathic LMW proteinuria in Japan is likely to be identical to Dent's disease in the United Kingdom. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|