Oxygen and oxidative stress in the perinatal period
| Autor: | Torres-Cuevas, Isabel, Parra-Llorca, Anna, Sánchez-Illana, Angel, Nuñez-Ramiro, Antonio, Lozano, Sheila, Kuligowski, Julia, Cháfer-Pericás, Consuelo, Cernada, María, Escobar, Justo, Vento, Máximo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Resuscitation GSH reduced glutathione Clinical Biochemistry HPLC-MS/MS high-performance liquid chromatography coupled to tandem mass spectrometry IUGR intrauterine growth retardation AA arachidonic acid Review Article medicine.disease_cause ppO partial pressure of oxygen (mmHg) Biochemistry Hypoxic Ischemic Encephalopathy GC-MS/MS gas chromatography coupled to tandem mass spectrometry IsoFs Isofurans 0302 clinical medicine SpO2 arterial oxygen saturation (expressed in %) NOS nitric oxide synthase lcsh:QH301-705.5 HIF hypoxia inducible factor PGF placental growth factor NeuroFs Neurofurans lcsh:R5-920 Asphyxia Neonatorum FiO2 oxygen inspiratory fraction 0.21–1.0) GPx glutathione peroxidase GSSG oxidized glutathione Ischemia-reperfusion IsoPs Isoprostanes PaO2/paO2 partial pressure of oxygen in arterial blood (mmHg) CS cesarean section VEGF vascular endothelial growth factor Anesthesia NeuroPs Neuroprostanes Female medicine.symptom PIVO2 intervillous (placenta) partial pressure of oxygen (mmHg) lcsh:Medicine (General) Infant Premature NADPH phosphorylated nicotine adenine dinucleotide Positive pressure Brain damage RNS reactive nitrogen species 03 medical and health sciences ROS reactive oxygen species 030225 pediatrics SOD superoxide dismutase medicine Humans Asphyxia XO xanthine oxidase business.industry AF amniotic fluid Organic Chemistry Infant Newborn DHA docosahexanoic acid Newborn DR delivery room kPa kilopascal XD xanthine dehydrogenase Clinical trial Oxygen Oxidative Stress 030104 developmental biology Clinical research lcsh:Biology (General) High-risk pregnancy NFκB nuclear factor kappa B Lipid Peroxidation NAC N-acetyl-cysteine CAT catalase business EPO erythropoietin Oxidative stress Biomarkers BPD bronchopulmonary dysplasia |
| Zdroj: | Redox Biology Redox Biology, Vol 12, Iss, Pp 674-681 (2017) |
| ISSN: | 2213-2317 |
| Popis: | Fetal life evolves in a hypoxic environment. Changes in the oxygen content in utero caused by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the mother lead to increased free radical production and correlate with perinatal outcomes. In the fetal-to-neonatal transition asphyxia is characterized by intermittent periods of hypoxia ischemia that may evolve to hypoxic ischemic encephalopathy associated with neurocognitive, motor, and neurosensorial impairment. Free radicals generated upon reoxygenation may notably increase brain damage. Hence, clinical trials have shown that the use of 100% oxygen given with positive pressure in the airways of the newborn infant during resuscitation causes more oxidative stress than using air, and increases mortality. Preterm infants are endowed with an immature lung and antioxidant system. Clinical stabilization of preterm infants after birth frequently requires positive pressure ventilation with a gas admixture that contains oxygen to achieve a normal heart rate and arterial oxygen saturation. In randomized controlled trials the use high oxygen concentrations (90% to 100%) has caused more oxidative stress and clinical complications that the use of lower oxygen concentrations (30–60%). A correlation between the amount of oxygen received during resuscitation and the level of biomarkers of oxidative stress and clinical outcomes was established. Thus, based on clinical outcomes and analytical results of oxidative stress biomarkers relevant changes were introduced in the resuscitation policies. However, it should be underscored that analysis of oxidative stress biomarkers in biofluids has only been used in experimental and clinical research but not in clinical routine. The complexity of the technical procedures, lack of automation, and cost of these determinations have hindered the routine use of biomarkers in the clinical setting. Overcoming these technical and economical difficulties constitutes a challenge for the immediate future since accurate evaluation of oxidative stress would contribute to improve the quality of care of our neonatal patients. Graphical abstract fx1 Highlights • Fetal life elapses in a low oxygen environment. • Hypoxia and Hyperoxia after birth cause oxidative stress and free radical derived conditions. • Asphyxia causes acute and long-term complications. • Preterm infants are susceptible to free radical associated diseases. • The use of lower oxygen to stabilize preterm infants improves clinical outcome. • Oxidative stress biomarkers correlate with clinical outcomes. |
| Databáze: | OpenAIRE |
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