The Drosophila simulans Y chromosome interacts with the autosomes to influence male fitness
| Autor: | David J. Hosken, Manmohan Sharma, C. R. Archer, R. M. Stephens |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine Genetics Male Autosome biology biology.organism_classification Y chromosome 010603 evolutionary biology 01 natural sciences Chromosomes 03 medical and health sciences 030104 developmental biology Evolutionary biology Y Chromosome Y linkage Epistasis Animals Drosophila simulans Genetic Fitness Drosophila melanogaster Allele Drosophila (subgenus) Gene Ecology Evolution Behavior and Systematics |
| Zdroj: | Journal of evolutionary biology. 30(10) |
| ISSN: | 1420-9101 |
| Popis: | The Y chromosome should degenerate because it cannot recombine. However, male-limited transmission increases selection efficiency for male-benefit alleles on the Y, and therefore, Y chromosomes should contribute significantly to variation in male fitness. This means that although the Drosophila Y chromosome is small and gene-poor, Y-linked genes are vital for male fertility in Drosophila melanogaster and the Y chromosome has large male fitness effects. It is unclear whether the same pattern is seen in the closely related Drosophila simulans. We backcrossed Y chromosomes from three geographic locations into five genetic backgrounds and found strong Y and genetic background effects on male fertility. There was a significant Y-background interaction, indicating substantial epistasis between the Y and autosomal genes affecting male fertility. This supports accumulating evidence that interactions between the Y chromosome and the autosomes are key determinants of male fitness. |
| Databáze: | OpenAIRE |
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