The Effects of Subconjunctival Mitomycin-C on Glaucoma Filtration Surgery in Rabbits
| Autor: | Richard L. Watnick, Gregory L. Skuta, Victor M. Elner, Terry J. Bergstrom, W. Scott Wilkinson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures Administration Topical Mitomycin Eye disease medicine.medical_treatment Glaucoma Cicatrix Intraoperative Period Random Allocation Postoperative Complications Ophthalmology medicine Glaucoma surgery Animals Prospective Studies Bleb (cell biology) Intraocular Pressure Lagomorpha biology business.industry Mitomycin C biology.organism_classification medicine.disease Combined Modality Therapy eye diseases Surgery Rabbits sense organs business |
| Zdroj: | Archives of Ophthalmology. 109:1725 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.1991.01080120109038 |
| Popis: | A prospective, randomized, masked, placebo-controlled study was performed to determine whether a single, intraoperative subconjunctival application of a 0.5-mg/mL solution of mitomycin-C enhances the success of full-thickness filtration surgery in rabbits. Compared with control eyes, mitomycin-C-treated eyes showed significant increases in bleb duration from 8.1 +/- 2.4 to 68.0 +/- 20.8 days and in intraocular pressure reduction from 6.0 +/- 3.0 to 63.6 +/- 21.5 days. Histopathologic evaluation confirmed the inhibitory effects of mitomycin-C on fibrovascular, fibrocellular, and collagenous organization of the filtering blebs that resulted in their preservation. Transient, superficial, corneal vascularization anterior to the bleb occurred in all mitomycin-C-treated eyes. No other clinical or pathologic signs of undesirable side effects were noted. We studied the effectiveness and safety of a single intraoperative application of mitomycin-C in prolonging the success of filtration surgery in rabbits and its potential for similar use in humans. |
| Databáze: | OpenAIRE |
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