Combination of sentinel lymph node mapping and uterine frozen section examination to reduce side-specific lymphadenectomy rate in endometrial cancer: a Turkish Gynecologic Oncology Group study (TRSGO-SLN-002)
| Autor: | Ozguc Takmaz, Ilker Kahramanoglu, Mete Güngör, Salih Taşkın, Nedim Tokgozoglu, Ali Ayhan, Duygu Altın, Cagatay Taskiran, Mehmet Faruk Köse, Emine Karabuk, Hasan Turan, M. Murat Naki, Macit Arvas, Fırat Ortaç, Dogan Vatansever |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Turkey medicine.medical_treatment Sentinel lymph node Uterus Gynecologic oncology Risk Factors medicine Frozen Sections Humans Aged Aged 80 and over Frozen section procedure Group study business.industry Sentinel Lymph Node Biopsy Endometrial cancer Obstetrics and Gynecology Middle Aged medicine.disease Endometrial Neoplasms Sentinel lymph node mapping medicine.anatomical_structure Oncology Lymphatic Metastasis Lymph Node Excision Lymphadenectomy Female Radiology Lymph Nodes Sentinel Lymph Node business Carcinoma Endometrioid |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 30(7) |
| ISSN: | 1525-1438 |
| Popis: | ObjectiveThis study aimed to find out whether side-specific pelvic lymphadenectomy can be omitted without compromising diagnostic efficacy according to “reflex frozen section” analysis of the uterus in case of sentinel lymph node (SLN) mapping failure.MethodsPatients who underwent surgery for endometrial cancer with an SLN algorithm were stratified as low-risk or high-risk according to the uterine features on the final pathology reports. Two models for low-risk patients were defined to omit side-specific pelvic lymphadenectomy: strategy A included patients with endometrioid histology, grade 1–2, and Results372 endometrial cancer patients were analyzed. 230 patients (61.8%) had endometrioid grade 1 or 2 tumors with ConclusionReflex frozen section examination of the uterus can be a feasible option to decide whether side-specific pelvic lymphadenectomy is necessary for all the patients who failed to map with an SLN algorithm. If low-risk factors are found on frozen section examination, side-specific pelvic lymphadenectomy can be omitted without compromising diagnostic efficacy for lymphatic spread. |
| Databáze: | OpenAIRE |
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