The rag Locus of Porphyromonas gingivalis Contributes to Virulence in a Murine Model of Soft Tissue Destruction
| Autor: | Robert A. Whiley, Xiaoju Shi, Stuart C. Fawell, Marie-Claire Faray-Kele, Shirley A. Hanley, Lucinda M. C. Hall, Michael A. Curtis, Joseph Aduse-Opoku |
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| Rok vydání: | 2007 |
| Předmět: |
Virulence
biology Virulence Factors Immunology Mutant Locus (genetics) biology.organism_classification Molecular Pathogenesis Microbiology Disease Models Animal Mice Infectious Diseases Bacterial Proteins Antigen Bacteroidaceae Infections Animals Parasitology Bacterial outer membrane Receptor Porphyromonas gingivalis Bacteroidaceae Gene Deletion |
| Zdroj: | Infection and Immunity. 75:2071-2074 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.01785-06 |
| Popis: | The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection. |
| Databáze: | OpenAIRE |
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