One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents
| Autor: | Dattatraya N. Pansare, Nayeem A. Mulla, Devanand B. Shinde, Vikas R. Shende, Chandrakant D. Pawar |
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| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Antifungal Agents Clinical Biochemistry Sulforhodamine B Pharmaceutical Science Aspergillus flavus Microbial Sensitivity Tests Biochemistry HeLa Structure-Activity Relationship chemistry.chemical_compound Candida albicans Drug Discovery Humans Organic chemistry Microwaves Cytotoxicity Molecular Biology Dose-Response Relationship Drug Molecular Structure biology Chemistry Organic Chemistry Aspergillus niger biology.organism_classification Antimicrobial Anti-Bacterial Agents MCF-7 Cells Thiazolidines Molecular Medicine Dimethylformamide HeLa Cells Nuclear chemistry |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:3569-3573 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2014.05.051 |
| Popis: | A one-pot, three-component, microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one ( 4a – n ) was carried out by using N , N -dimethylformamide as a solvent with high product yield. Among these synthesized compounds ( 4f , 4g , 4l and 4m ) were found to be a broad spectrum molecule active against all bacterial and fungus strains tested, except fungus Aspergillus niger . Amongst the compounds ( 4g , 4l and 4m ) were found to be more potent than respective standard drugs used in the experiment against Candida albicans , Staphylococcus aureus and Aspergillus flavus , respectively. All synthesized compounds were also tested for their cytotoxic activity against HeLa and MCF-7 cell lines by the sulforhodamine B (SRB) assay. This study shows that all compounds were non-cytotoxic in nature, and confirmed their antimicrobial specificity apart from any general cytotoxicity. |
| Databáze: | OpenAIRE |
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