Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
| Autor: | Antoon Opperhuizen, Morten Poulsen, Dick T. H. M. Sijm, Hubert Dirven, Gerhard Rogler, Eric Houdeau, Nicolaj S Bischoff, Simone G. J. van Breda, David Michael Gott, Jacqueline Castenmiller, Theo M. de Kok, Henk Van Loveren, Jacco J. Briedé, Yolanda I. Chirino, Agnes G. Oomen |
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| Přispěvatelé: | University of Zurich, Bischoff, Nicolaj S, School for Oncology and Developmental Biology [Maastricht] (GROW), Maastricht University [Maastricht]-Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Netherlands Food and Consumer Product Safety Authority (NVWA), Universidad Autonoma Metropolitana - Iztapalapa, Norwegian Institute of Public Health [Oslo] (NIPH), FOOD STANDARDS AGENCY LONDON GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Technical University of Denmark [Lyngby] (DTU), University hospital of Zurich [Zurich], Office of Risk Assessment and Research of Netherlands Food and Consumer Product Safety Authority (NVWA) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
3 NANOSCALE tio2 nanoparticles 1607 Spectroscopy 010501 environmental sciences 01 natural sciences in-vivo INTESTINAL EPITHELIUM Dietary Exposure lcsh:Chemistry Adverse health effect Adverse Outcome Pathway Medicine Ingestion TiO2 Coloring Agents lcsh:QH301-705.5 Spectroscopy Titanium dna-damage General Medicine 3. Good health Computer Science Applications food safety 10219 Clinic for Gastroenterology and Hepatology [SDV.TOX]Life Sciences [q-bio]/Toxicology nanomaterial 1606 Physical and Theoretical Chemistry Risk assessment TiO 2 food.ingredient PIGMENT-GRADE 1503 Catalysis review 610 Medicine & health Catalysis Inorganic Chemistry 03 medical and health sciences food Immune system mode of action Environmental health Toxicity Tests 1312 Molecular Biology 1706 Computer Science Applications Animals Humans EXPOSURE Physical and Theoretical Chemistry Adverse effect Molecular Biology E171 0105 earth and related environmental sciences food additive 1604 Inorganic Chemistry business.industry titanium dioxide Food additive Organic Chemistry adverse health effects technology industry and agriculture risk-assessment toxicity Food safety sprague-dawley 030104 developmental biology oral toxicity lcsh:Biology (General) lcsh:QD1-999 Nanoparticles nano size business oral exposure 1605 Organic Chemistry |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 207, p 207 (2021) Bischoff, N S, de Kok, T M, Sijm, D T H M, van Breda, S G, Briedé, J J, Castenmiller, J J M, Opperhuizen, A, Chirino, Y I, Dirven, H, Gott, D, Houdeau, E, Oomen, A G, Poulsen, M, Rogler, G & van Loveren, H 2021, ' Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System ', International Journal of Molecular Sciences, vol. 22, no. 1, 207 . https://doi.org/10.3390/ijms22010207 International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2021, 22 (1), pp.207. ⟨10.3390/ijms22010207⟩ |
| ISSN: | 1661-6596 1422-0067 |
| DOI: | 10.3390/ijms22010207 |
| Popis: | Titanium dioxide (TiO2) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO2 and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (2 warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO2, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO2 and nano-sized TiO2 in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO2. |
| Databáze: | OpenAIRE |
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