Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology
| Autor: | Mittal Darji, Michael A. Repka, Ajinkya M. Bhagurkar, Priyanka Thipsay, Suresh Bandari, Prit Lakhani |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Hot Temperature Polymers Chemistry Pharmaceutical Plastics extrusion Pharmaceutical Science Polyethylene glycol 030226 pharmacology & pharmacy Article Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Hypromellose Derivatives Plasticizers Adhesives Tensile Strength PEG ratio medicine Technology Pharmaceutical Albuterol Response surface methodology Anti-Asthmatic Agents Cellulose Pharmacology chemistry.chemical_classification Plasticizer Mouth Mucosa Administration Buccal Polymer Drug Liberation chemistry Chemical engineering 030220 oncology & carcinogenesis Extrusion Swelling medicine.symptom |
| Zdroj: | The Journal of pharmacy and pharmacology. 71(3) |
| ISSN: | 2042-7158 |
| Popis: | Objectives To investigate the effects of formulation composition on the physico-chemical and drug release properties of mucoadhesive buccal films prepared by melt extrusion technology, using a response surface methodology. Methods Salbutamol sulphate, an antiasthmatic drug was used for this study. Klucel hydroxypropylcellulose (HPC) EF (film-forming polymer), Benecel hydroxypropylmethylcellulose (HPMC) K-15M (drug release retardant) and polyethylene glycol (PEG) 4500 (plasticiser) were the three independent factors utilised for the study. The responses were fitted to a full quadratic model and P-values for each of the factors were used to determine their significance on the film characteristics. Key findings Films were successfully extruded using the corotating twin-screw extruder. The torque during extrusion was found to be significantly affected by all the three factors and no interaction between factors was observed. A significant interaction was observed between HPC and PEG 4500 for stiffness of films. For disintegration time and swelling index, a significant interaction was found between HPC and HPMC. The in vitro % drug release was directly correlated with HPMC content and not with other factors and varied from 69–89% at 4 h. Conclusions The influence of extrusion process and formulation parameters on salbutamol sulphate films was elucidated, indicating the use of melt extrusion as a feasible method for film preparation. |
| Databáze: | OpenAIRE |
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