Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial
| Autor: | Nicola Anstice, Joanna Black, Angela Wadham, William R. Bobier, Yannan Jiang, Shuan Dai, Raiju J. Babu, Lisa S. Kearns, Natalie Walker, Varsha Parag, Cindy X. Guo, Lionel Kowal, Jayshree South, Sandra E Staffieri, Carly S.Y. Lam, Benjamin Thompson, Robert F. Hess, Michelle Jenkins, Tina Y. Gao, Peter C. K. Pang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity genetic structures Adolescent Visual Acuity Amblyopia 03 medical and health sciences Young Adult 0302 clinical medicine Double-Blind Method Ophthalmology Occlusion medicine Humans Young adult Strabismus Child Anisometropia business.industry Middle Aged medicine.disease eye diseases Sensory Systems Clinical trial Stereoscopic acuity Eyeglasses Treatment Outcome 030221 ophthalmology & optometry Female Every Four Weeks medicine.symptom Sensory Deprivation business 030217 neurology & neurosurgery Optometry Follow-Up Studies |
| Zdroj: | Ophthalmicphysiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). 38(2) |
| ISSN: | 1475-1313 |
| Popis: | PURPOSE Optical treatment alone can improve visual acuity (VA) in children with amblyopia, thus clinical trials investigating additional amblyopia therapies (such as patching or videogames) for children require a preceding optical treatment phase. Emerging therapies for adult patients are entering clinical trials. It is unknown whether optical treatment is effective for adults with amblyopia and whether an optical correction phase is required for trials involving adults. METHODS We examined participants who underwent optical treatment in the Binocular Treatment for Amblyopia using Videogames (BRAVO) clinical trial (ANZCTR ID: ACTRN12613001004752). Participants were recruited in three age groups (7 to 12, 13 to 17, or ≥18 years), and had unilateral amblyopia due to anisometropia and/or strabismus, with amblyopic eye VA of 0.30-1.00 logMAR (6/12 to 6/60, 20/40 to 20/200). Corrective lenses were prescribed based on cycloplegic refraction to fully correct any anisometropia. VA was assessed using the electronic visual acuity testing algorithm (e-ETDRS) test and near stereoacuity was assessed using the Randot Preschool Test. Participants were assessed every four weeks up to 16 weeks, until either VA was stable or until amblyopic eye VA improved to better than 0.30 logMAR, rendering the participant ineligible for the trial. RESULTS Eighty participants (mean age 24.6 years, range 7.6-55.5 years) completed four to 16 weeks of optical treatment. A small but statistically significant mean improvement in amblyopic eye VA of 0.05 logMAR was observed (S.D. 0.08 logMAR; paired t-test p < 0.0001). Twenty-five participants (31%) improved by ≥1 logMAR line and of these, seven (9%) improved by ≥2 logMAR lines. Stereoacuity improved in 15 participants (19%). Visual improvements were not associated with age, presence of strabismus, or prior occlusion treatment. Two adult participants withdrew due to intolerance to anisometropic correction. Sixteen out of 80 participants (20%) achieved better than 0.30 logMAR VA in the amblyopic eye after optical treatment. Nine of these participants attended additional follow-up and four (44%) showed further VA improvements. CONCLUSIONS Improvements from optical treatment resulted in one-fifth of participants becoming ineligible for the main clinical trial. Studies investigating additional amblyopia therapies must include an appropriate optical treatment only phase and/or parallel treatment group regardless of patient age. Optical treatment of amblyopia in adult patients warrants further investigation. |
| Databáze: | OpenAIRE |
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