ROSIGLITAZONE RELIEVES ACUTE ETHANOL-INDUCED HANGOVER IN SPRAGUE–DAWLEY RATS
| Autor: | Sookyung Kim, Tae Woo Jung, Chul Woo Ahn, Wan Sub Shim, Hyun Chul Lee, Bong Soo Cha, Eun Seok Kang, Ji Young Lee |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Blotting Western Immunoblotting Aldehyde dehydrogenase Mitochondria Liver Mitochondrion Rats Sprague-Dawley Rosiglitazone chemistry.chemical_compound Downregulation and upregulation Western blot Internal medicine Animals Hypoglycemic Agents Medicine Interpersonal Relations Social Behavior Ethanol biology medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction business.industry Acetaldehyde Central Nervous System Depressants General Medicine Rats Up-Regulation Endocrinology chemistry Cyanamide biology.protein Thiazolidinediones business medicine.drug |
| Zdroj: | Alcohol and Alcoholism. 41:231-235 |
| ISSN: | 1464-3502 0735-0414 |
| Popis: | Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor. |
| Databáze: | OpenAIRE |
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