Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility
Autor: | Thomas J. Mariani, Robert H. Lim, Lester Kobzik, Adriana S. Leme, Alexey V. Fedulov, Zhiping Yang, Morten Dahl |
---|---|
Rok vydání: | 2007 |
Předmět: |
Pulmonary and Respiratory Medicine
Allergy Offspring Clinical Biochemistry Inflammation Allergic inflammation Mice Immune system Pregnancy medicine Animals Humans Molecular Biology Lung Maternal-Fetal Exchange Asthma Oligonucleotide Array Sequence Analysis Vehicle Emissions Titanium Air Pollutants biology Gene Expression Profiling Cell Biology Articles respiratory system medicine.disease respiratory tract diseases Ovalbumin Gene Expression Regulation Maternal Exposure Immunology biology.protein Cytokines Female Particulate Matter medicine.symptom Immunity Maternally-Acquired |
Zdroj: | American journal of respiratory cell and molecular biology. 38(1) |
ISSN: | 1535-4989 |
Popis: | Maternal immune responses can promote allergy development in offspring, as shown in a model of increased susceptibility to asthma in babies of ovalbumin (OVA)-sensitized and -challenged mother mice. We investigated whether inflammatory responses to air pollution particles (diesel exhaust particles, DEP) or control "inert" titanium dioxide (TiO(2)) particles are enhanced during pregnancy and whether exposure to particles can cause increased neonatal susceptibility to asthma. Pregnant BALB/c mice (or nonpregnant controls) received particle suspensions intranasally at Day 14 of pregnancy. Lung inflammatory responses were evaluated 48 hours after exposure. Offspring of particle- or buffer-treated mothers were sensitized and aerosolized with OVA, followed by assays of airway hyperresponsiveness (AHR) and allergic inflammation (AI). Nonpregnant females had the expected minimal response to "inert" TiO(2). In contrast, pregnant mice showed robust and persistent acute inflammation after both TiO(2) and DEP. Genomic profiling identified genes differentially expressed in pregnant lungs exposed to TiO(2). Neonates of mothers exposed to TiO(2) (and DEP, but not PBS) developed AHR and AI, indicating that pregnancy exposure to both "inert" TiO(2) and DEP caused increased asthma susceptibility in offspring. We conclude that (1) pregnancy enhances lung inflammatory responses to otherwise relatively innocuous inert particles; and (2) exposures of nonallergic pregnant females to inert or toxic environmental air particles can cause increased allergic susceptibility in offspring. |
Databáze: | OpenAIRE |
Externí odkaz: |