Innate Sensing of Chitin and Chitosan
| Autor: | Stuart M. Levitz, Chelsea L. Bueter, Charles A. Specht |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pulmonology
Cryptococcus Chitin Insect Plant Science Pearls Chitosan chemistry.chemical_compound 0302 clinical medicine Plant Immunity lcsh:QH301-705.5 media_common chemistry.chemical_classification 0303 health sciences biology Pattern recognition receptor Fungal Diseases Innate Immunity Chemistry Infectious Diseases Receptors Pattern Recognition Medicine Signal Transduction lcsh:Immunologic diseases. Allergy media_common.quotation_subject Immunology macromolecular substances Polysaccharide Microbiology Cell wall 03 medical and health sciences Bacterial Proteins Virology Genetics Parasitic Diseases Animals Humans Particle Size Molecular Biology Biology 030304 developmental biology fungi Immunity biology.organism_classification Asthma Immunity Innate carbohydrates (lipids) Nematode lcsh:Biology (General) chemistry Parasitology lcsh:RC581-607 030215 immunology |
| Zdroj: | PLoS Pathogens PLoS Pathogens, Vol 9, Iss 1, p e1003080 (2013) |
| ISSN: | 1553-7374 1553-7366 |
| Popis: | Chitin is the second most common polysaccharide found in nature. It is present in crustacean shells, insect exoskeletons, parasitic nematode eggs and gut linings, and in the cell wall of fungi. The deacetylated derivative of chitin, chitosan, is less common but is particularly evident in certain species of fungi, such as Cryptococcus, and the cyst wall of Entamoeba. How mammals sense and respond to these polymers is not well understood, and conflicting reports on their immunological activity have led to some controversy. Despite this, promising translational applications that exploit the unique properties of chitin and chitosan are being developed. |
| Databáze: | OpenAIRE |
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