Trabecular bone microarchitecture in mild primary hyperparathyroidism
| Autor: | V. Lo Cascio, L. Dalle Carbonare, Mt Valenti, Paola Ballanti, Sandro Giannini, Giuseppe Realdi, Francesco Bertoldo, B. Giovanazzi |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Pathology endocrine system diseases Endocrinology Diabetes and Metabolism Urology bone histomorphometry Bone remodeling Ilium Endocrinology Bone Density Biopsy medicine Humans primary hyperparathyroidism fracture microarchitecture Aged Endocrine disease medicine.diagnostic_test business.industry Middle Aged medicine.disease Hyperparathyroidism Primary Postmenopause Trabecular bone medicine.anatomical_structure Increased risk Female Bone Remodeling business Cancellous bone Primary hyperparathyroidism Bone structure |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1720-8386 |
| Popis: | Primary hyperparathyroidism (PHPT) is a common endocrine disease. High levels of PTH cause demineralization of bone and increased risk of fracture. On the other hand, the effect of PHPT on bone structure is more ambiguous. The aim of this study was to evaluate the effect of PHPT on cancellous bone volume, structure, and microarchitecture. Thirteen transiliac biopsy specimens taken in untreated post-menopausal women aged 65+/-5 yr with primary hyperparathyroidism were compared with 13 biopsies taken in normal women aged 66+/-6 yr. None of the patients presented any other disorder affecting bone metabolism. In these samples we evaluated the direct and indirect histomorphometric parameters of bone microarchitecture using an image analysis system consisting of an epifluorescent microscope (Leica DMR) connected to an analogic 3 CCD camera (Sony DXC 390P) and a computer equipped with specific software for histomorphometric analyses. No significant differences between PHPT patients and controls in cancellous bone volume, trabecular thickness, and number were found. Two-dimensional parameters showed a preserved microarchitecture in PHPT patients. On the other hand, indirect parameters of microarchitecture [Marrow Star Volume (MSV) and Trabecular Bone Pattern Factor (TBPf)] showed a significant compromising of microarchitecture in these patients. PHPT patients have similar structural parameters to normal subjects. Concerning microarchitecture, indirect approach by MSV and TBPf shows a significant compromising of connectivity. These results can explain trabecular fragility observed in clinical studies on PHPT. |
| Databáze: | OpenAIRE |
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